24A Soft X-ray Tomography

Publications

2025

    • M.-H. Liu, Z.-J. Gao, W.-Y. Huang, C.-H. Hsiao, V. Chen, L.-J. Lai, Z.-J. Lin, M. D.-S. Hua, C.-C. Hsieh, E.-Y. Chuang, J.-S. Yu*, K.-T. Wong*. New NIR-Activated Organic Molecule-Based Nanocomposite as an Efficient Sensitizer for Photothermal and Photodynamic Therapy of Cancer. Adv. Healthc. Mater. 14, 2404418 (2025). [Link]
    • C.-W. Lai, C.-Y. Lin, M.-C. Tsai, W.-J. Chen, C.-C. Hsieh, Z.-J. Lin, L.-J. Shen, Y.-L. Chen, L.-J. Lai, S.-H. Chen*, Y.-H. Shih*. From AI to action: Antimicrobial peptides engineered by generative adversarial networks (GANs)-A novel approach to combat resistant Bacteria. Chem. Eng. J. 519, 164905 (2025). [Link]
    • S. S. Dwitya, K.-S. Lin*, L.-J. Lai*, N. V. Mdlovu, Z.-J. Lin*, C.-C. Hsieh, M. D.-S. Hua. Intracellular trafficking of nanostructured MOF-303 for targeted liver cancer therapy: A study using soft X-ray tomography. Mater. Today Chem. 47, 102793 (2025). [Link]
    • M.-H. Cheng, H.-H. Wang, M. D.-S. Hua, H.-F. Kuo, Z.-J. Lin, C.-C. Hsieh, C.-H. Hsin, C.-Y. Li, S.-C. Wang, Y.-H. Chen, S.-H. Wu, W.-L. Liu*, P.-L. Liu*. Magnolol facilitates mitochondrial-peroxisome dysfunction and induces oxeiptosis in lung cancer cells following transfer via tunneling nanotubes. Biomed. Pharmacother. 187, 118126 (2025). [Link]

    2024

    • W.-L. Huang, C.-L. Chen, Z.-J. Lin, C.-C. Hsieh, M. D.-S. Hua, C.-C. Cheng, T.-H. Cheng, L.-J. Lai*, C.-R. Chang*. Soft X-ray tomography analysis of mitochondria dynamics in Saccharomyces cerevisiae. Biol. Direct. 19, 126 (2024). [Link]
    • C.-C. Hsieh, Z.-J. Lin, L.-J. Lai*. Minimizing ice contamination during specimen preparation for cryo-soft X-ray tomography and cryo-electron tomography. J. Struct. Biol.: X 10, 100113(2024) [Link]
    • Y.-S. Yu, Y.-Y. Liang, C.-C. Hsieh, Z.-J. Lin, P.-H. Cheng, C.-C. Cheng, S.-P. Chen, L.-J. Lai* and Kevin C.-W. Wu*. Downsizing and soft X-ray tomography for cellular uptake of interpenetrated metal-organic frameworks. J. Mater. Chem. B 12, 6079 (2024).  (cover page of this issue)  [Link]

    2023

    • P.-H. Tang, P. B. So, Z.-J. Lin, C.-C. Hsieh, L.-J. Lai, C.-H. Lin*. Structural identification of multidimensional metal–organic frameworks using soft x-ray tomography. J. Chin. Chem. Soc. 70, 1108 (2023). [Link]
    • M. D.-S. Hua, C.-C. Hsieh, Y.-H. Lin, Z.-J. Lin and L.-J. Lai*. Soft x-ray tomographic study or iron deposits under iron overload condition in human SK-Hep-1. AIP Conf. Proc. 2990, 020010 (2023). [Link]
    • L.-J. Lai*, Z.-J. Lin, D.-J. Wang, G.-C. Yin, C.-C. Hsieh, Y.-H. Lin, B.-Y.Chen and C.-Y. Lee. Development of a cryo-soft x-ray tomography at Taiwan photon source. AIP Conf. Proc. 2990, 040004 (2023). [Link]
    • C.-C. Hsieh*, Z.-J.Lin, and L.-J. Lai. Construction of low humidity biosafety level-2 laboratory for cryo-sample environment for soft x-ray tomography imaging at Taiwan photon source. AIP Conf. Proc. 2990, 040008 (2023). [Link]
    2022
    • Y.-J. Su*, G.-C. Yin, M.-Y. Hsu, H.-W. Fu, H.-S. Fung. Design of a plane grating with multilayer coating for the soft X-ray tomography beamline. J. Phys. Conf. Ser. 2380, 012059 (2022). [Link]

    2019

    • Y.-J. Su*, L.-J. Huang, H. -W. Chen, B.-Y. Liao, C. -F. Chang, L.-J. Lai, S.-H. Chang. Multifunctional Beamline Chamber Featuring Diagnostic Devices, Differential Pumping, and Laser Alignment for Endstation Optics. AIP Conf. Proc. 2054, 060051 (2019). [Link]

    2018
    • L.-J. Lai*, G.-C. Yin, Y.-J. Su, S.-Y. Chiang, D.-J Wang, Z.-J. Lin, C.-C. Hsieh, C.-W. Chen, L. -J. Huang, T.-W. Chen, B. -Y. Chen. Development of a Correlation of Soft X-Ray Tomography with Fluorescence Microscopy at Taiwan Photon Source. Microsc. Microanal. 24 (Suppl 2), 394 (2018). [Link]
    • Z.-J. Lin*, C.-W. Chen, C.-C. Hsieh, T.-W. Chen, D.-J. Wang, S. -Y. Chiang and L.-J. Lai*. Integration of Soft X-ray Tomography and High Resolution Fluorescence Microscopy. Microsc. Microanal. 24, 238 (2018). [Link]
    • B.-Y. Chen*, G.-C. Yin, M.-Y. Hsu, X.-Y. Li, D.-J. Wang, L.-J. Lai. The detector adjustment system of Taiwan Photon Source 24A. Proc. MEDSI2018, Paris, Publishing ISBN: 978-3-95450-207-3 (2018). [Link]

    2017

    • L.-J. Lai*, Z.-J. Lin, C.-C. Hsieh, Y. -J. Su, D.-J. Wang, S.-Y. Chiang, G.-C. Yin. Correlation of Soft X-ray Tomography with Fluorescence Microscopy in Biological Study. Microsc. Microanal. 23 (Suppl 1), 974 (2017). [Link]
    2016
    • H.-Y. Chen, D. M.-L. Chiang, Z.-J. Lin, C.-C. Hsieh, G.-C. Yin, I.-C. Weng, P. Guttmann, S. Werner, K. Henzler, G. Schneider, L.-J. Lai*, F.-T. Liu*. Nanoimaging granule dynamics and subcellular structures in activated mast cells using soft X-ray tomography. Sci. Rep. 6, 34879 (2016). [Link]
    • Y.-J. Su*, H. -W. Fu, S.-C. Chung, H.-S. Fung, D.-C. Liu, L.-J. Huang, H.-Y. Yan, Y.-C. Chou, G. C. Yin, and L. J. Lai. Design of the soft x-ray tomography beamline at Taiwan photon source. AIP Conf. Proc. 1741, 030046 (2016). [Link]
    • M.-H. Lee*, C.-H. Chang, S.-H. Chang, D.-G. Liu, Y.-J. Su, L.-J. Huang, C.-C. Chen, C.-C. Chiu, L. Lee, H.-Y. Yan, C.-Y. Chang, L.-J. Lai. Developing white beam components of TPS beamline 24A. Proc. MEDSI2016, Barcelona (2016). [Link]

    Find a Beamline

    24A Home

    Specifications

    Optical Layout

    Endstations

    Publications

    BL Schedule

    Staff

    User Info

    Gallery (Visitors)

    Gallery (Activities)

    Gallery


     Contacts

    Endstation

    —+886-3-578-0281 Ext. 2242

    BL Spokesperson

    Lin, Zi-Jing (林子敬)
    lin.zj@nsrrc.org.tw
    +886-3-578-0281 Ext. 7204

    BL Manager/Local Contact

    Chen, Jian-Hua (陳建樺)
    chen.jh@nsrrc.org.tw
    +886-3-578-0281 Ext. 7309


    Techniques

    • Soft X-ray Tomography (SXT)
    • Fluorescence Structured-Illumination Microscopy (SIM)

    Disciplines

    • Medicine and drug discovery
    • X-ray optics
    • Biomedical Engineering
    • Soft X-ray imaging
    • Bio-medical imaging

    General Information

    • Source: Bending Magnet
    • Energy Range: 260-2,600 eV
    • Focused Spot Size: 20 ~ 30 nm in 2D imaging; 50 nm in 3D imaging
    • Status: Open







    National Synchrotron Radiation Research Center

    101 Hsin-Ann Road, Hsinchu Science Park, Hsinchu, Taiwan 30076

    +886-3-578-0281